Upstream Fermentation

Media development

  • Seeding and production
  • Batch and Fed-batch
  • TSE free
  • Chemically defined available

Fermentation development

  • DoE approach
  • Scalable: benchtop (2L) to pilot and production
  • Process parameter optimization
  • Identification of critical process parameters
  • Feeding protocols
  • Aerobic and anaerobic

Fermentation scale from 2L to 6,000L

  • Glass – 2L, 5L, 10L
  • Single use – capacity up to 30L
  • Stainless steel – 20L, 50L, 120L, 500L, 600L, 5,000L, 6,000L

Centrifugation

  • Disk stack centrifuge
  • Tubular Bowl High Speed
  • Chamber Bowl centrifuge
  • Basket Centrifuge
  • Bottle centrifuge

Homogenization

Filtration (UF/DF)

  • Tangential flow
  • Hollow fiber
  • Flat sheet cassette systems

Media development

  • Seeding and production
  • Batch and Fed-batch
  • TSE free
  • Chemically defined available

Fermentation development

  • DoE approach
  • Scalable: benchtop (2L) to pilot and production
  • Process parameter optimization
  • Identification of critical process parameters
  • Feeding protocols
  • Aerobic and anaerobic

Fermentation scale from 2L to 6,000L

  • Glass – 2L, 5L, 10L
  • Single use – capacity up to 30L
  • Stainless steel – 20L, 50L, 120L, 500L, 600L, 5,000L, 6,000L

Centrifugation

  • Disk stack centrifuge
  • Tubular Bowl High Speed
  • Chamber Bowl centrifuge
  • Basket Centrifuge
  • Bottle centrifuge

Homogenization

Filtration (UF/DF)

  • Tangential flow
  • Hollow fiber
  • Flat sheet cassette systems
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