Upstream Fermentation
Media development
- Seeding and production
- Batch and Fed-batch
- TSE free
- Chemically defined available
Fermentation development
- DoE approach
- Scalable: benchtop (2L) to pilot and production
- Process parameter optimization
- Identification of critical process parameters
- Feeding protocols
- Aerobic and anaerobic
Fermentation scale from 2L to 6,000L
- Glass – 2L, 5L, 10L
- Single use – capacity up to 30L
- Stainless steel – 20L, 50L, 120L, 500L, 600L, 5,000L, 6,000L
Centrifugation
- Disk stack centrifuge
- Tubular Bowl High Speed
- Chamber Bowl centrifuge
- Basket Centrifuge
- Bottle centrifuge
Homogenization
Filtration (UF/DF)
- Tangential flow
- Hollow fiber
- Flat sheet cassette systems
Media development
- Seeding and production
- Batch and Fed-batch
- TSE free
- Chemically defined available
Fermentation development
- DoE approach
- Scalable: benchtop (2L) to pilot and production
- Process parameter optimization
- Identification of critical process parameters
- Feeding protocols
- Aerobic and anaerobic
Fermentation scale from 2L to 6,000L
- Glass – 2L, 5L, 10L
- Single use – capacity up to 30L
- Stainless steel – 20L, 50L, 120L, 500L, 600L, 5,000L, 6,000L
Centrifugation
- Disk stack centrifuge
- Tubular Bowl High Speed
- Chamber Bowl centrifuge
- Basket Centrifuge
- Bottle centrifuge
Homogenization
Filtration (UF/DF)
- Tangential flow
- Hollow fiber
- Flat sheet cassette systems